ANALYZER CLD 88
Nitric oxide analyzer for liquid NO samples
The ANALYZER CLD 88 offers precise measurement of nitric oxide. The extremely high sensitivity and fast response time of the NO-analyzer allows the detection of concentrations in the range of parts per trillion. Ease of use guarantee flexibility for standard applications as well as scientific research. In combination with the liquid purge vessel the CLD 88 measures nitrites, nitrates and nitrosothiols in biological fluids like plasma, urine and sera down to pMol concentrations. The easy and accurate data recording and analysis is guaranteed by using the PowerChrom™️ software from EDAQ.
The ANALYZER CLD 88 is an extremely fast and accurate instrument with a detection range down to 0.06 ppb and a linearity of ±1% over the full scale.
User friendly software package
PowerChrom is a simple to use software for the collection, display and analysis of NO measurements.
Wide application spectrum
The setup can be easily adapted so that NO can be measured from many different sources. Applications are manifold and range from biomedical and pharmaceutical to laboratory applications.
| NO measurement | Measuring range – Gas samples: 0.1 – 5000 ppb Measuring range – Liquid samples: pico- to millimolar Min. detectable concentration: 0.06 ppb* Noise at zero-point (1σ): 0.03 ppb* Zero drift: <0.5 ppb per 6 h Linearity: ± 1% full scale Lag time: < 0.5 s Rise time (T90): < 100 ms Sample flow: selectable type 1 or 3 (110 or 330 ml/min) Sampling rate: 40 Hz internal, 10 Hz output |
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| Interface | Analog output: 20 mA into 600 Ohm, galvanic isolated | |
| General | Temperature range: 10 – 40 °C Humidity tolerance: 5 – 95% rel. humidity (non-condensing) Ozone generator: internal, maintenance free (no external supply gas required) Ozone scrubber: internal, thermal, maintenance free Power consumption: 400 VA Supply voltage: 100 – 240 V / 50 – 60 Hz Weight: 24 kg Dimensions: H x W x D: 135 x 500 x 540 mm (5¼ x 19 x 17 “) System includes: ANALYZER CLD 88, sample tube type 3, mains cable and operator’s manual |
(*) depending on sample flow
(Note: NO-calibration gases and the PowerChrom system with software and PC are not part of delivery; Documentation in English language only)
ECO MEDICS reserves the right to change these specifications without notice.
Optional solution for easy and flexible chromatographic data analysis
| PowerChromTM system with software from EDAQ (optional) | Sampling: up to 100 Hz Channels: max. 2 Resolution: up to 24 bits (16-bit ACD + oversampling) Interface: USB 2.0 or 1.1 to Windows XP Supply voltage: 100 – 240 V / 50 – 60 Hz Power consumption: 6 VA Weight: 1.75 kg |
EDAQ reserves the right to change the specifications of the PowerChrom system and software without notice.
LIQUID Applications
- Reduction of nitrate using vanadium(III) and hydrochloric acid at 90˚C.
- Reduction of nitrite using iodide and acetic acid
- Reduction of nitrosothiols using a modified Saville reaction or Cu/Cystine.
Your Advantage
- Fast and precise
- Compact
- User friendly software package
- Biomedical and laboratory applications
- Measurement of gas and liquid samples
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References
- Bailey, J. D. et al. Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation. Cell Reports 28, 218-230.e7 (2019).
- Dhawan, V., Janero, D. & Ellis, J. Detection of Nitros(yl)ated Metabolites of Nitric Oxide (NO) In Vivo by Gas-Phase Chemiluminescence Assay. Current Protocols in Pharmacology 35, 12.10.1-12.10.9 (2006).
- Feelisch, M. et al. Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo. FASEB J. 16, 1775–1785 (2002).
- Kulshrestha, P., McKinstry, K. C., Fernandez, B. O., Feelisch, M. & Mitch, W. A. Application of an Optimized Total N-Nitrosamine (TONO) Assay to Pools: Placing N-Nitrosodimethylamine (NDMA) Determinations into Perspective. Environ. Sci. Technol. 44, 3369–3375 (2010).
- Rassaf, T., Bryan, N. S., Kelm, M. & Feelisch, M. Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic. Biol. Med. 33, 1590–1596 (2002).
- Rodriguez, J., Maloney, R. E., Rassaf, T., Bryan, N. S. & Feelisch, M. Chemical nature of nitric oxide storage forms in rat vascular tissue. Proc. Natl. Acad. Sci. U.S.A. 100, 336–341 (2003).
- Thøgersen, R. et al. Inulin-fortification of a processed meat product attenuates formation of nitroso compounds in the gut of healthy rats. Food Chemistry 302, 125339 (2020).
FeNO Testing
Exhaled nitric oxide analysis for asthma management and PCD screening in cooperative and non-cooperative patients
ANALYZER CLD 88 sp – FeNO analysis by single and multiple breath testing; bronchial, alveolar and nasal FeNO
Pulmonary Function Testing
Detection and monitoring of ventilation inhomogeneity and small airway diseases such as asthma, cystic fibrosis and COPD
EXHALYZER D – Nitrogen washout by single breath or multiple breath (SBW or MBW), breathing pattern (TBFVL), FRC, LCI, moment ratios and slope analysis
Infant Pulmonary Function Testing
Suitable for cooperative and non-cooperative patients from infants >3kg body weight to adults
EXHALYZER D – Breathing pattern (TBFVL), FRC, LCI and SOT analysis for patients > 3 kg body weight
Liquid NO analysis
Nitric oxide analyzer for liquid samples from biomedical or pharmaceutical applications
ANALYZER CLD 88 – Liquid NO detection in combination with liquid purge vessel and chromatographic software