ANALYZER CLD 88 sp

The reference method for FeNO testing from newborn to adult patients

The ANALYZER CLD 88 sp FeNO analyzer is the reference for continuous, simultaneous measurement and display of NO values, flow rate and volume of the exhaled breath. This sensitive instrument guarantees reproducible and reliable results. It is approved in accordance to CE MDD for clinical use and fully compliant to the 2005 ATS/ERS recommendations for FeNO analysis. One instrument for all applications, from infants (>3 kg) to adults.

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High sensitivity and reproducibility

The ANALYZER CLD 88 sp offers high sensitivity and speed as demanded in clinical and research applications. NO concentrations down to 0.1 ppb can be detected.

Numerous application options in one system

The ANALYZER CLD 88 sp can be used for FeNO testing on infants (>3 kg), children and adults. Single breath tests for cooperative patients as well as multiple breath tests for non-cooperative patients are possible. The instrument can also measure nasal and alveolar NO. Tests can be carried out online or offline.

Options for extended application range

Several options are available for the ANALYZER CLD 88 sp. The DENOX 88 module supplies NO free air and controls the expiratory flow during the single breath test. An offline NO collection kit is available for tests remote from the instrument.

Easy to use

Performing an NO measurement is very simple with the ANALYZER CLD 88 sp. The instrument is controlled by the SPIROWARE® software, which let’s the user start, record and evaluate a measurement with a few mouse clicks only. All key parameters and graphs are displayed in the results section and the screen can be customized for individual preferences.

NO-measurement Measuring ranges: 0.1-5000 ppb
Min. detectable concentration: 0.06 ppb *
Zero drift: <0.5 ppb per 6 h
Linearity: ± 1% full scale
Lag time: < 0.5 s, software compensated
Rise time (T90): < 100 ms
Sample flow: selectable type 1 or 3 (110 or 330 ml/min)
Flow measurement Measuring range:
±0.5 l/s (DSR small: VD 1.9 ml, optional)
±1.5 l/s (DSR medium: VD 7.2 ml)
±16 l/s (Spirette)
Min. detectable flow: 0.6 ml
Accuracy: ±2%
General Temperature range: 10-40 °C
Humidity tolerance: 5-95% rel. humidity (non-condensing)
Ozone Generator: internal, maintenance free (no external supply gas required)
Power consumption: 400 VA
Supply voltage: 100-240 V / 50-60 Hz
Interface: RS-232 (Standard)
Weight: 24 kg
Dimensions: HxWxD: 135 x 500 x 540 mm (5¼ x 19 x 17 “)
System requirements Intel Core i5 type processor or higher, compliant to the Council Directive 93/42 EEC concerning medical devic-es and the European Safety Standard EN 60601-1 (e.g. ViewMedic Clinico 222C3, Rein Medical GmbH, 47877 Willich, Germany), Microsoft Windows WIN 7 or higher and .NET Framework 4.0 and MS Visual C++ 2010
16 MB of RAM, 10GB of free disk space, XGA or better graphics and USB 2.0 port

(*) Depending on sample flow

System includes: ANALYZER CLD 88 sp, integrated ultrasonic Spirometer, sample tube type 3, mains- and RS-232-cable, operator’s Manual, SPIROWARE® 3.x software
(Note: Computer, printer, NO-calibration gases and NO free air supply are not part of delivery)

ECO MEDICS reserves the right to change these specifications without notice.

Product Overview Brochure – English
ANALYZER CLD 88 sp Brochure (FeNO test) – English
SPIROWARE® Software Brochure – English

Applications

  • Single breath tests for cooperative patients
  • Multiple breath tests for non-cooperative patients
  • Nasal nitric oxide measurements
  • Offline NO collection kit
  • Alveolar FeNO analysis

Your Advantage

  • Noninvasive detection of lung inflammation (e.g. asthma)
  • Verification of anti-inflammatory treatment
  • Detection of non-responders
  • Various flow ranges for research applications (JNO, Calv calculations)
  • PCD screening
  • CE MDD 93/42 approved for clinical use
  • Compliance with the “ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005”

Application Videos

FeNO Test with the ANALYZER CLD 88 Series

This video demonstrates how to perform a standard single breath FeNO test with the ANALYZER CLD 88 Series.

Calibration of the ANALYZER CLD 88 Series 

This video demonstrates step by step how to calibrate the ANALYZER CLD 88 Series. Calibration prior to FeNO measurement is important to enable efficient lung function measurement and to obtain clinically useful and reproducible data.

ATS / ERS reference

The ANALYZER CLD 88 sp with SPIROWARE® 3.x is CE MDD (0483) approved for clinical use. The chemiluminescence detection method is the only ATS / ERS recommended measurement principle for exhaled Nitric Oxide analysis (FeNO test – Gold Standard) to fulfill the requirements for detection limit, response time and measurement range.

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References

  1. ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005. Am J Respir Crit Care Med 171, 912–930 (2005).
  2. Baraldi, E. and de Jongste, J.C. on behalf of the Task Force. Measurement of exhaled nitric oxide in children, 2001. European Respiratory Journal 20, 223–237 (2002).
  3. Dweik, R. A. et al. An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications. Am J Respir Crit Care Med 184, 602–615 (2011).
  4. Hall, G. L., Reinmann, B., Wildhaber, J. H. & Frey, U. Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure. J. Appl. Physiol. 92, 59–66 (2002).
  5. Heffler, E. et al. Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Multidisciplinary Respiratory Medicine 15, (2020).
  6. Högman, M. & Meriläinen, P. Extended NO analysis in asthma. J Breath Res 1, 024001 (2007).
  7. Högman, M., Thornadtsson, A., Hedenstierna, G. & Meriläinen, P. A practical approach to the theoretical models to calculate NO parameters of the respiratory system. J. Breath Res. 8, 016002 (2014).
  8. Holgersen, M. G., Marthin, J. K. & Nielsen, K. G. Proof of Concept: Very Rapid Tidal Breathing Nasal Nitric Oxide Sampling Discriminates Primary Ciliary Dyskinesia from Healthy Subjects. Lung 197, 209–216 (2019).
  9. Horváth, I. et al. A European Respiratory Society technical standard: exhaled biomarkers in lung disease. European Respiratory Journal 49, (2017).
  10. Korten, I. et al. Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls. J. Cyst. Fibros. 17, 105–108 (2018).
  11. Olivieri, M. et al. Reference values for exhaled nitric oxide (reveno) study. Respir. Res. 7, 94 (2006).
  12. Shapiro, A. J. et al. Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia. A Technical Paper on Standardized Testing Protocols. Annals ATS 17, e1–e12 (2019).

FeNO Testing

Exhaled nitric oxide analysis for asthma management and PCD screening in cooperative and non-cooperative patients

ANALYZER CLD 88 sp – FeNO analysis by single and multiple breath testing; bronchial, alveolar and nasal FeNO

Pulmonary Function Testing

Detection and monitoring of ventilation inhomogeneity and small airway diseases such as asthma, cystic fibrosis and COPD

EXHALYZER D – Nitrogen washout by single breath or multiple breath (SBW or MBW), breathing pattern (TBFVL), FRC, LCI, moment ratios and slope analysis

Infant Pulmonary Function Testing

Suitable for cooperative and non-cooperative patients from infants >3kg body weight to adults

EXHALYZER D – Breathing pattern (TBFVL), FRC, LCI and SOT analysis for patients > 3 kg body weight

Liquid NO analysis

Nitric oxide analyzer for liquid samples from biomedical or pharmaceutical applications

ANALYZER CLD 88 – Liquid NO detection in combination with liquid purge vessel and chromatographic software