Pulmonary Function Testing from infant to adult patients
The EXHALYZER® D offers various lung function tests for infants (>3 kg), children and adult patients. The modular system is easily upgradable and fully compliant with the ATS / ERS recommendations for infant and pediatric pulmonary function testing.
The EXHALYZER D offers the “gold standard” in accuracy for clinical application.
Flexible and upgradable
The EXHALYZER D can be extended with several optional modules. The nitrogen washout bypass system allows the performance of multiple washout tests, while the optional NO measurement module allows the non-invasive detection of lung inflammation (fractional exhaled nitric oxide, FeNO), for example. The instrument works independently of the temperature, humidity or viscosity of the gas.
Wide application range
One system for pulmonary function testing for all patients: From infants to school age children to adults, all age groups can be tested on the EXHALYZER D. In particular, the EXHALYZER D is ideally suited for infants (>3 kg). The low airflow restriction prevents interference with the infant’s spontaneous breathing. Furthermore, infant sedation is not required for standard tests. Respiratory conditions can be easily followed up from infants to adults.
ATS / ERS compliance
The instrument and software are fully compliant to the recent ATS / ERS recommendations for pulmonary function testing and exhaled nitric oxide measurements.
All tests are easily started, executed, recorded and evaluated by the SPIROWARE® software. Display options include numerical and graphical data analysis. Respiratory conditions can be monitored over time, from newborn to adult age.
® EXHALYZER and SPIROWARE are registered trademarks of ECO MEDICS.
|Flow and pressure measurement||Flow range: ± 0.5 l/s (DSR small), ± 1.5 l/s (DSR medium), ± 8 l/s (DSR large)
Volume resolution: 0.6 / 1 ml
Accuracy: ± 2%
Dead space: 1.9 ml (DSR small), 7.2 ml (DSR medium), 20 ml (DSR large)
Resistance: <0.15 kPa / 0.5 l/min
Sampling frequency: 200 Hz
|FRC / LCI infant measurement (option)||Principle: SF6 washin / washout
Application: spont. breathing
Cont. flow: adjust. up to 250 ml/s
|Nitrogen washout FRC module (option)||Principle: N2 washout by 100% O2
Maneuvers: Single and multiple breath tests
Application: spont. breathing
Cont. flow: up to 1250 ml/s
|NO measurement (option)||Measurement range: 01. To 5000 ppb
Detection limit: 0.06 ppb*
Rise time (T90): <100 ms
Sampling rate: 10 Hz
Sample flow rate: select. 100 or 300 ml/min*
|CO2 measurement (option)||Principle: Mainstream, self calibrating
Measurement range: 0 to 14 %
0 to 14 kPa
Accuracy: 2 mm Hg (0 to 40 mm Hg), 5% of read. (> 40 mm Hg), 10% of read. (> 77 mm Hg)
Detection limit: 0.06 ppb*
Rise time (T90): <100 ms
|Oxygen measurement (option)||Principle: Side stream, laser diode
Measurement range: 2 to 100%
Rise time (T90): 100 ms
Sampling frequency: 100 Hz
Sample flow: 200 ml/min
|Airway occlusion module (option)||Modes of operation: Automatic (flow triggered), manual
Response time : <10 ms
Closing time: select. 50 to 1500 ms
Pressure range: -120 to 120 mbar
|General||Temperature range: 10-40 °C
Humidity tolerance: 5-95% rel. humidity (non-condensing)
Supply voltage : 100 – 240 V, 50 – 60 Hz
Power required: 230 VA max.
Data interface: USB Mini
Data acquisition: SPIROWARE 3.x
Weight (basic module): 5 kg (w/o PC and printer)
Dimensions (h x w x d) : 100 x 550 x 400 mm (4 x 21.7 x 15.8 inch)
|System requirements||Intel Core i5 type processor or higher, compliant to the Council Directive 93/42 EEC concerning medical devic-es and the European Safety Standard EN 60601-1 (e.g. ViewMedic Clinico 222C3, Rein Medical GmbH, 47877 Willich, Germany), Microsoft Windows WIN 7, .NET Framework 4.0 or higher, 16 Mbyte RAM, 10 GB free space on hard disk, XGA Graphics or better, USB 2.0 or higher|
(*) depending on sample flow
(Note: PC, Printer, calibration gases and zero-air supply are not part of delivery.)
ECO MEDICS reserves the right to change these specifications without notice.
- Tidal Breathing Analysis
- FRC and ventilation inhomogeneity measurements
- Small airway monitoring: Lung Clearance Index (LCI) and Slope 3 analysis (SnIII)
- Multiple and single breath nitrogen washout measurements (N2MBW, N2SBW)
- SF6 multiple breath washout
- Single occlusion lung mechanics analysis
- Capnography and Oximetry
- Optional multiple and single breath FENO analysis
- Integrated system for pulmonary function testing suitable for infants (>3 kg) to school age and adult patients
- No sedation required for standard tests
- Noninvasive detection of lung inflammation (fractional exhaled NO, FeNO test)
- Fully upgradeable
Tidal breathing flow volume analysis for non-cooperative infants (> 3kg)
Functional residual capacity and ventilation inhomogeneity measurements (LCI) during normal tidal breathing by innert gas multiple breath washin /-out technique, no sedation and patient cooperation required
FRC/LCI PRE-SCHOOL TO ADULT
Functional residual capacity (FRC) and ventilation inhomogeneity measurements (LCI) during normal tidal breathing by Multiple Breath Nitrogen Washout Principle using 100% oxygen.
FeNO measurements to detect airway inflammation by multiple and single breath technique in accordance with ATS / ERS recommendations.
CLD 88 EXHALYZER – the reference method for chemiluminescence nitric oxide measurement
INTERESTED IN THIS PRODUCT?
- Anagnostopoulou, P. et al. Normative data for multiple breath washout outcomes in school-aged Caucasian children. European Respiratory Journal 55, (2020).
- Arianto, L. et al. Sensitivity of multiple breath washout to detect mild-to-moderate asthma in adolescence. J Allergy Clin Immunol Pract 7, 2052-2054.e5 (2019).
- Bates, J. H., Schmalisch, G., Filbrun, D. & Stocks, J. Tidal breath analysis for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. European Respiratory Journal 16, 1180–1192 (2000).
- Gustafsson, P. M., Robinson, P. D., Lindblad, A. & Oberli, D. Novel methodology to perform sulfur hexafluoride (SF6)-based multiple-breath wash-in and washout in infants using current commercially available equipment. J. Appl. Physiol. 121, 1087–1097 (2016).
- Hasler, D. et al. A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test. PLoS Comput. Biol. 15, e1007079 (2019).
- Kentgens, A.-C., Oppelaar, M. & Merkus, P. A new breeze from an inspiring past: normality with multiple breath washout in school-aged children. European Respiratory Journal 55, (2020).
- Kjellberg, S., Houltz, B. K., Zetterström, O., Robinson, P. D. & Gustafsson, P. M. Clinical characteristics of adult asthma associated with small airway dysfunction. Respir Med 117, 92–102 (2016).
- Manco, A. et al. Small airway dysfunction predicts excess ventilation and dynamic hyperinflation during exercise in patients with COPD. Respiratory Medicine: X 2, 100020 (2020).
- Ratjen, F. et al. Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial. The Lancet Respiratory Medicine 7, 802–809 (2019).
- Robinson, P. D. et al. Consensus statement for inert gas washout measurement using multiple- and single- breath tests. European Respiratory Journal 41, 507–522 (2013).
- Robinson, P. D. et al. Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement. Am J Respir Crit Care Med 197, e1–e19 (2018).
- Robinson, P. D., Goldman, M. D. & Gustafsson, P. M. Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration 78, 339–355 (2009).
- Robinson, P. D., Kadar, L., Lindblad, A. & Gustafsson, P. M. Effect of change of body position in spontaneous sleeping healthy infants on SF6-based multiple breath washout. European Respiratory Journal 54, (2019).
- Schmidt, M. N. et al. What it takes to implement regular longitudinal multiple breath washout tests in infants with cystic fibrosis. Journal of Cystic Fibrosis 0, (2020).
- Singer, F., Houltz, B., Latzin, P., Robinson, P. & Gustafsson, P. A realistic validation study of a new nitrogen multiple-breath washout system. PLoS ONE 7, e36083 (2012).
- Skov, L. et al. Lung compartment analysis assessed from N2 multiple-breath washout in children with cystic fibrosis. Pediatric Pulmonology 55, 1671–1680 (2020).
- Stahl, M. et al. Multiple Breath Washout Is Feasible in the Clinical Setting and Detects Abnormal Lung Function in Infants and Young Children with Cystic Fibrosis. RES 87, 357–363 (2014).