The European Respiratory Society (ERS) has recently published a new technical standard on the measurement of nasal nitric oxide to improve the diagnosis of Primary Ciliary Dyskinesia (PCD) in preschool age children. PCD is a rare genetic disorder that can lead to chronic lung, ear and sinus infections. Most people with PCD have symptoms from birth onwards and early diagnosis is essential to prevent irreversible airway damage and poor quality of life. According to the technical standard, the most reliable method for PCD diagnosis is based on measuring nasal nitric oxide with a chemiluminescence device, such as the ECO MEDICS ANALYZER CLD 88. In small children, the test can be performed during normal breathing, while a sample tube is attached to one nostril. Older children are asked to hold their breath or to breathe against a resistor. The new technical standard provides guidance for sampling, analysis and reporting of nasal nitric oxide measurements in preschool children.

Link to article:
Beydon, N. et al. Nasal nitric oxide measurement in children for the diagnosis of primary ciliary dyskinesia: European Respiratory Society technical standard. European Respiratory Journal 61, (2023).