The impact of SPIROWARE® 3.3.1 with improved sensor accuracy on N2-MBW data was was elaborated by Paul Robinson and colleagues from Australia, Canada and the UK. They re-analysed multiple breath washout data from 1036 test occasions derived from measurements with the EXHALYZER®D. Their analysis showed that lung clearance index (LCI) values from SPIROWARE® 3.3.1 were lower, and higher LCI values were more affected. In more detail, they found that the inter-test reproducibility of LCI improved and the within-subject and between-subject variability of LCI decreased when analysed with the new software version.
Robinson and colleagues gave a positive outlook for SPIROWARE® 3.3.1 with improved sensor accuracy: “The results of our analyses are reassuring for both published research studies and clinical trials to date and those planned in the future with the Exhalyzer®D device.”
They concluded their article with the crucial message that the new algorithms “did not change observed treatment effects nor interpretation” and that their “data provide reassurance that previously reported results are still relevant after correction of the sensor cross-sensitivity error”.
Follow the link to read the full article:
“Impact of cross-sensitivity error correction on representative nitrogen-based multiple breath washout data from clinical trials” by Robinson and colleagues (2021)